Gene regulatory functions of Drosophila Fish-hook, a high mobility group domain Sox protein
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منابع مشابه
Gene regulatory functions of Drosophila Fish-hook, a high mobility group domain Sox protein
In this study we investigate the gene regulatory functions of Drosophila Fish-hook (Fish), a high mobility group (HMG) Sox protein that is essential for embryonic segmentation. We show that the Fish HMG domain binds to the vertebrate Sox protein consensus DNA binding sites, AACAAT and AACAAAG, and that this binding induces an 85 degrees DNA bend. In addition, we use a heterologous yeast system ...
متن کاملThe Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS development.
We describe the isolation and analysis of the Drosophila fish-hook (fish) gene, which encodes a novel member of the SOX subgroup of High Mobility Group (HMG) domain proteins that exhibit similarity to the mammalian testis determining factor, SRY. The fish gene is initially expressed in a pair-rule-like pattern which is rapidly replaced by strong neuroectoderm expression. fish null mutants exhib...
متن کاملSox100B, a Drosophila group E Sox-domain gene, is required for somatic testis differentiation.
Sex determination mechanisms are thought to evolve rapidly and show little conservation among different animal species. For example, the critical gene on the Y chromosome, SRY, that determines sex in most mammals, is not found in other animals. However, a related Sox domain transcription factor, SOX9, is also required for testis development in mammals and exhibits male-specific gonad expression...
متن کاملThe Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation.
We have cloned and characterised a member of the High Mobility Group superfamily of genes from Drosophila, Sox70D, which is closely related to the mammalian testis determining gene SRY. Sox70D corresponds to the dominant wing mutation Dichaete. Homozygous deletions of the Sox70D gene and recessive lethal Dichaete alleles have a variable embryonic segmentation phenotype. Dichaete is expressed in...
متن کاملThe Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm.
In the Drosophila embryonic central nervous system, neural stem cells, called neuroblasts, acquire fates in a position-specific manner. Recent work has identified a set of genes that functions along the dorsoventral axis to enable neuroblasts that develop in different dorsoventral domains to acquire distinct fates. These genes include the evolutionarily conserved transcription factors ventral n...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1998
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(98)00050-1